Fluoroquinolones are NOT recommended in Marfan Syndrome
As you might have heard, there has been a lot of talk during the last months about the use of fluoroquinolone antibiotics in Marfan Syndrome.
A couple days ago, the FDA (Food and Drug Administration) has issued a warning concerning the use of this particular antibiotic in Marfan patients after the publication of several scientific research publications showing an increased risk of aortic aneurysm and dissections when using this type of antibiotics in Marfan Syndrome patients and related disorders (links see bellow).
Other adverse effects of this particular antibiotic were also previously reported by the EMA (European Medicine agency), but the risk of aortic aneurysm has yet to be added to this list. Several national health organisation have already updated their recommandations.
- Article published by the Marfan Foundation
- Fluoroquinolones and collagen associated severe adverse events: a longitudinal cohort study. (2015)
- Risk of Aortic Dissection and Aortic Aneurysm in Patients Taking Oral Fluoroquinolone (2015)
- Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study (2018)
- Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice (2018)
- Fluoroquinolones and the risk of aortopathy: A systematic review and meta-analysis.
- Patients at Risk for Aortic Rupture Often Exposed to Fluoroquinolones During Hospitalization.
- more links
image from humannhealth.com